- EAN13
- 9782705699420
- Éditeur
- Hermann
- Date de publication
- 21/10/1997
- Langue
- français
- Fiches UNIMARC
- S'identifier
Livre numérique
-
Aide EAN13 : 9782705699420
-
Fichier EPUB, avec DRM Adobe
- Impression
-
216 pages
- Copier/Coller
-
43 pages
- Partage
-
6 appareils
- Lecture audio
-
Impossible
21.99 -
Fichier EPUB, avec DRM Adobe
The present work emphasises the importance of microbial physiology,
biochemistry, genetics and evolu tion in the study of biosynthesis. It takes
into account the considerable advances made in the field in the last twenty
years by the introduction of gene cloning and sequencing and by the
exponential development of physical methods such as X-ray crystallography of
proteins. After dealing with the kinetics of bacterial growth and the most
recent developments in the mechanisms of cellular permeability, a chapter
treats the phenomenon of allostery, indispensable for the understanding of
many phenomena described in the rest of the book. Enzyme induction is then
described from the phenomenological, genetic, and mechanistic points of view.
Logically, the study of transcription follows, as well as that of repression
in anabolic systems. The facts uncovered lead to the generalization of the
concepts of negative and positive regulation. A study of the genetic code, of
the transfer RNAs, and of the cognate aminoacyl-tRNA synthetases is an
obligatory introduction to the phenomenon of attenuation. Then, eighteen
chapters deal with the methodology of the elucidation of biosynthetic pathways
and with these actual pathways including nitrogen fixation, polysaccharide and
lipid biosyntheses, biosynthesis of amino acids, nucleotides and
deoxynucleotides, water-soluble vitamins and coenzymes, metabolites deri ved
from mevalonic acid (ubiquinones and menaquinones, carotenoids and sterols),
tetrapyrrole com pounds (heme, chlorophyll and phycobilin chromophores) and,
finally, cobalamins.
biochemistry, genetics and evolu tion in the study of biosynthesis. It takes
into account the considerable advances made in the field in the last twenty
years by the introduction of gene cloning and sequencing and by the
exponential development of physical methods such as X-ray crystallography of
proteins. After dealing with the kinetics of bacterial growth and the most
recent developments in the mechanisms of cellular permeability, a chapter
treats the phenomenon of allostery, indispensable for the understanding of
many phenomena described in the rest of the book. Enzyme induction is then
described from the phenomenological, genetic, and mechanistic points of view.
Logically, the study of transcription follows, as well as that of repression
in anabolic systems. The facts uncovered lead to the generalization of the
concepts of negative and positive regulation. A study of the genetic code, of
the transfer RNAs, and of the cognate aminoacyl-tRNA synthetases is an
obligatory introduction to the phenomenon of attenuation. Then, eighteen
chapters deal with the methodology of the elucidation of biosynthetic pathways
and with these actual pathways including nitrogen fixation, polysaccharide and
lipid biosyntheses, biosynthesis of amino acids, nucleotides and
deoxynucleotides, water-soluble vitamins and coenzymes, metabolites deri ved
from mevalonic acid (ubiquinones and menaquinones, carotenoids and sterols),
tetrapyrrole com pounds (heme, chlorophyll and phycobilin chromophores) and,
finally, cobalamins.
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